The effect of female sexual hormones on the intestinal and serum cytokine response after traumatic brain injury: different roles for estrogen receptor subtypes

M Khaksari, Z Keshavarzi… - Canadian Journal of …, 2013 - cdnsciencepub.com
The purpose of this study was to evaluate the effect of female sexual hormones on intestinal
and serum cytokines following traumatic brain injury (TBI). Adult female rats were
ovariectomized and distributed among the following 9 groups:(i) sham trauma,(ii) TBI
(Marmarou's method),(iii) vehicle (dimethylsulfoxide) treated,(iv) estrogen (E2) treated,(v)
progesterone (P) treated,(vi) treated with E2+ P,(vii) propylpyrazole triol (PPT) treated,(viii)
diarylpropionitrile (DPN) treated, and (ix) control. PPT and DPN are estrogen receptor αand …
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